Synthesis and Cytotoxic Activity of 5-Benzoylhexahydropyrimidine Derivatives
نویسندگان
چکیده
The reaction of ethyl benzoylacetate with formaldehyde and natural amino acid ester hydrochlorides in acetate buffer (AcONa/AcOH, pH 4.0) at room temperature afforded 41–61% new 5-benzoylhexahydropyrimidine derivatives. synthesized compounds were evaluated for their vitro cytotoxic activity against normal (HEK293) tumor cell lines (Jurkat, HepG2). T-Lymphoblastic leukemia Jurkat cells turned out to be most sensitive the examined hexahydropyrimidine Ethyl 5-benzoyl-1,3-bis[2-ethoxy-1-(4-hydroxybenzyl)-2-oxoethyl]hexahydropyrimidine-5-carboxylate showed highest all tested lines.
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ژورنال
عنوان ژورنال: Russian Journal of Organic Chemistry
سال: 2021
ISSN: ['1608-3393', '1070-4280']
DOI: https://doi.org/10.1134/s1070428021070204